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Leader Biomedical | Technologies | eCOO Technology

eCOO® Technology

eCOO® Technology is Leader Biomedical’s unique proprietary platform that encompasses several technology handles for cleaning, sterilising, and impregnating biological and synthetic grafts. eCOO® Technology provides a mild and efficient platform to clean and sterilise tissue with limited use of chemicals. Research has shown that the use of scCO2 minimally affects the structural integrity of tissue grafts when compared to conventional processing techniques. scCO2 treatment also removes medullary tissues responsible for adverse immune response.

Leader Biomedical has successfully applied eCOO® Technology to process human-derived cancellous and cortical bone, and tendons for over 10 years in Europe. eCOO® Technology has also been used to develop a dental membrane, derived from porcine tissue, for applications in guided bone and tissue regeneration.



Freeze-drying, also known as lyophilisation, is a well known technique which extracts water in order to preserve solids. Nowadays, this technique is used to develop novel pharmaceuticals, biomaterials and a range of soft and hard tissues. Freeze-drying allows for gentle preservation, retaining the original 3D structure of a biomaterial or tissue which is important for graft-adherence when applied in the clinic. After the freeze-drying procedure is completed, products can be stored at room temperature and generally have a longer shelf-life compared to non-freeze-dried products. In addition, this procedure omits the use of (chemical) conservatives and leaves a smaller carbon-footprint as the need for cold storage facilities is not required.

We can offer freeze-drying services to its customers for a wide variety of products and production scales with a fully GMP-qualified Zirbus that offers condenser capacity of 40 kg/hour and measuring 60 cm by 80 cm. This technique can be used to freeze dry different types of soft and hard tissues which results in excellent storage conditions. In addition, freeze-drying services are offered for pharmaceutical products, such as powders manufactured by lyophilisation process, with complex structures or porous matrixes as well as coating with antibiotics.

Note: not all products in the corporate therapeutic solutions portfolios may be available in all regions/countries. Please refer to your local sales contact for more information.



eCOO® Technology

eCOO® Technology provides a mild and efficient platform to clean and sterilise tissue with limited use of chemicals by utilising the unique characteristics of supercritical carbon dioxide (scCO2)…

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MBCP® Technology

Leader Biomedical’s OssGro® synthetic bone grafts are produced with MBCP® Technology, a proprietary method for producing high quality synthetic bone grafts composed of 60% HA and 40% βTCP

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